TUSC5 Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Belongs to the CD225/Dispanin family. Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 17p13.3
Cellular Component:  cytoplasmic vesicle membrane; endomembrane system; integral component of membrane; perinuclear region of cytoplasm; plasma membrane
Biological Process:  cellular response to insulin stimulus; endosome to plasma membrane protein transport; glucose import in response to insulin stimulus; protein localization to plasma membrane; vesicle fusion to plasma membrane
Reference #:  Q8IXB3 (UniProtKB)
Alt. Names/Synonyms: BEC-1; brain endothelial cell derived gene-1; Dispanin subfamily B member 1; DSPB1; IFITMD3; interferon induced transmembrane protein domain containing 3; Interferon-induced transmembrane domain-containing protein D3; located at seventeen p thirteen point three 1; LOST1; Protein located at seventeen-p-thirteen point three 1; TARG1; trafficking regulator of GLUT4 (SLC2A4) 1; Trafficking regulator of GLUT4 1; TRARG1; Tumor suppressor candidate 5; TUSC5
Gene Symbols: TRARG1
Molecular weight: 19,254 Da
Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB