DENND2A Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  actin cytoskeleton; cytosol
Molecular Function:  Rab guanyl-nucleotide exchange factor activity
Biological Process:  protein transport; retrograde transport, endosome to Golgi
Reference #:  Q9ULE3 (UniProtKB)
Alt. Names/Synonyms: DEN2A; DENN domain containing 2A; DENN domain-containing protein 2A; DENN/MADD domain containing 2A; DENND2A; FAM31D; KIAA1277
Gene Symbols: DENND2A
Molecular weight: 113,853 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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DENND2A

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene