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MSH3
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Belongs to the DNA mismatch repair MutS family. MSH3 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of rat Ortholog: 2q12 |
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Cellular Component:
MutSbeta complex; nucleus
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Molecular Function:
centromeric DNA binding; damaged DNA binding; dinucleotide insertion or deletion binding; dinucleotide repeat insertion binding; DNA binding; double-stranded DNA binding; enzyme binding; guanine/thymine mispair binding; mismatched DNA binding; oxidized purine DNA binding; protein homodimerization activity; single guanine insertion binding; single-stranded DNA binding
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Biological Process:
DNA repair; maintenance of DNA repeat elements; mismatch repair; mitotic recombination; negative regulation of DNA recombination; positive regulation of helicase activity; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; spermatogenesis
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Reference #:
XP_001065837
(RefSeq)
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Alt. Names/Synonyms: Msh3; mutS homolog 3; mutS homolog 3 (E. coli)
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Gene Symbols: Msh3
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Molecular weight:
124,716 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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