DGKZ
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes. Activates PIP5K1A activity via generation of phosphatidic acid. Belongs to the eukaryotic diacylglycerol kinase family. Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
Chromosomal Location of rat Ortholog: 3q24 |
Cellular Component:
cytosol; glutamatergic synapse; lamellipodium; nuclear speck; nucleus; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse
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Molecular Function:
ATP binding; ATP-dependent diacylglycerol kinase activity; enzyme inhibitor activity; kinase activity; lipid kinase activity; metal ion binding; protein binding
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Biological Process:
diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; maintenance of postsynaptic density structure; mitotic G1 DNA damage checkpoint signaling; negative regulation of mitotic cell cycle; negative regulation of Ras protein signal transduction; negative regulation of T cell receptor signaling pathway; phosphatidic acid biosynthetic process; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; protein kinase C-activating G protein-coupled receptor signaling pathway; Ras protein signal transduction; regulation of synaptic transmission, glutamatergic
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Reference #:
O08560
(UniProtKB)
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Alt. Names/Synonyms: 104 kDa diacylglycerol kinase; DAG kinase zeta; Dagk6; DGK-IV; DGK-zeta; Dgkz; Diacylglycerol kinase zeta; Diglyceride kinase zeta
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Gene Symbols: Dgkz
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Molecular weight:
104,009 Da
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Basal Isoelectric point:
8.34
Predict pI for various phosphorylation states
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