ALDH5A1 Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Belongs to the aldehyde dehydrogenase family. Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of rat Ortholog: 17p11
Cellular Component:  mitochondrion
Molecular Function:  carboxylic acid binding; NAD binding; succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity
Biological Process:  acetate metabolic process; central nervous system development; galactosylceramide metabolic process; gamma-aminobutyric acid catabolic process; gamma-aminobutyric acid metabolic process; glucose metabolic process; glucosylceramide metabolic process; glutamate metabolic process; glutamine metabolic process; glutathione metabolic process; glycerophospholipid metabolic process; neurotransmitter catabolic process; oxidation-reduction process; post-embryonic development; protein homotetramerization; respiratory electron transport chain; short-chain fatty acid metabolic process; succinate metabolic process
Reference #:  P51650 (UniProtKB)
Alt. Names/Synonyms: aldehyde dehydrogenase 5 family, member A1; aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); Aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; Aldh5a1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Ssadh; SSDH; Succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
Gene Symbols: Aldh5a1
Molecular weight: 56,131 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene