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MVP
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of rat Ortholog: 1q37 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex
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Molecular Function:
identical protein binding; protein binding; protein kinase binding; protein phosphatase binding
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Biological Process:
cell population proliferation; ERBB signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein autophosphorylation; negative regulation of protein tyrosine kinase activity; protein activation cascade
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Reference #:
Q62667
(UniProtKB)
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Alt. Names/Synonyms: Major vault protein; MVP
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Gene Symbols: Mvp
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Molecular weight:
95,798 Da
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Basal Isoelectric point:
5.42
Predict pI for various phosphorylation states
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