SYNPO2 iso2 Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor. Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia. Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. Belongs to the synaptopodin family. Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle. 5 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 4q26
Cellular Component:  actin cytoskeleton; cytosol; focal adhesion; intracellular membrane-bounded organelle; nucleus; stress fiber; tethering complex; Z disc
Molecular Function:  14-3-3 protein binding; alpha-actinin binding; filamin binding; muscle alpha-actinin binding; protein binding; protein binding, bridging
Biological Process:  autophagosome assembly; chaperone-mediated autophagy
Reference #:  Q9UMS6-2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686G051; genethonin 2; Genethonin-2; Myopodin; synaptopodin 2; Synaptopodin-2; SYNP2; SYNPO2
Gene Symbols: SYNPO2
Molecular weight: 136,342 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
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SYNPO2 iso2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein