BAK1 Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Belongs to the Bcl-2 family. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial

Chromosomal Location of human Ortholog: 6p21.31

Cellular Component: BAK complex; Bcl-2 family protein complex; cytosol; endoplasmic reticulum; mitochondrial outer membrane; mitochondrion; pore complex

Molecular Function: BH domain binding; heat shock protein binding; identical protein binding; metal ion binding; porin activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; protein-folding chaperone binding; transmembrane transporter binding

Biological Process: activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; animal organ regeneration; apoptotic process; apoptotic process involved in blood vessel morphogenesis; apoptotic signaling pathway; B cell apoptotic process; B cell homeostasis; B cell negative selection; blood vessel remodeling; calcium ion transport into cytosol; cellular response to mechanical stimulus; cellular response to unfolded protein; cellular response to UV; endocrine pancreas development; endoplasmic reticulum calcium ion homeostasis; epithelial cell proliferation; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway in absence of ligand; fibroblast apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; limb morphogenesis; mitochondrial fusion; myeloid cell homeostasis; negative regulation of cell population proliferation; negative regulation of endoplasmic reticulum calcium ion concentration; negative regulation of gene expression; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of release of cytochrome c from mitochondria; peptidyl-serine phosphorylation; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of IRE1-mediated unfolded protein response; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of protein-containing complex assembly; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; post-embryonic camera-type eye morphogenesis; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to ethanol; response to fungus; response to gamma radiation; response to hydrogen peroxide; response to mycotoxin; response to organic cyclic compound; response to UV-C; response to xenobiotic stimulus; thymocyte apoptotic process; vagina development

Reference #: Q16611 (UniProtKB)

Alt. Names/Synonyms: Apoptosis regulator BAK; BAK; BAK-LIKE; BAK1; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; BCL2 antagonist/killer 1; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2L7; CDN1; MGC117255; MGC3887; pro-apoptotic protein BAK

Gene Symbols: BAK1

Molecular weight: 23,409 Da

Basal Isoelectric point: 5.66 Predict pI for various phosphorylation states

CST Pathways: Apoptosis Regulation | Mitochondrial Control of Apoptosis

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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BAK1

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