RGS12 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. Isoform 3 is brain specific. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component:  cell junction; condensed nuclear chromosome; cytoplasm; cytosol; dendrite; nuclear matrix; nucleolus; nucleus; plasma membrane
Molecular Function:  GTPase activator activity; GTPase activity; GTPase regulator activity
Biological Process:  G protein-coupled receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
Reference #:  O14924 (UniProtKB)
Alt. Names/Synonyms: DKFZp761K1617; DKFZp761K1817; regulator of G protein signaling 12; Regulator of G-protein signaling 12; regulator of G-protein signalling 12; RGS12
Gene Symbols: RGS12
Molecular weight: 156,357 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
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Protein Structure Not Found.

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