PCSK2 Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. Belongs to the peptidase S8 family. Furin subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 2 G1|2 70.89 cM
Cellular Component:  cytoplasmic vesicle; dendrite; extracellular region; extracellular space; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; nucleus; perikaryon
Molecular Function:  endopeptidase activity; hydrolase activity; peptidase activity; protein-containing complex binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  enkephalin processing; insulin processing; islet amyloid polypeptide processing; nervous system development; peptide hormone processing; protein autoprocessing; protein processing; proteolysis
Reference #:  P21661 (UniProtKB)
Alt. Names/Synonyms: 6330411F23Rik; AI839700; KEX2-like endoprotease 2; NEC 2; Nec-2; Nec2; Neuroendocrine convertase 2; OTTMUSP00000002995; PC2; Pcsk2; Phpp-2; Prohormone convertase 2; Proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; SPC2
Gene Symbols: Pcsk2
Molecular weight: 70,785 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene