Rb-like 2 Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of human Ortholog: 16q12.2
Cellular Component:  chromatin; chromosome; cytosol; nucleolus; nucleoplasm; transcription regulator complex
Molecular Function:  promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process:  cell cycle; cell differentiation; chromatin organization; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; regulation of cell division; regulation of lipid kinase activity; regulation of transcription by RNA polymerase II
Disease: Brunet-wagner Neurodevelopmental Syndrome
Reference #:  Q08999 (UniProtKB)
Alt. Names/Synonyms: 130 kDa retinoblastoma-associated protein; FLJ26459; p130; pRb2; RB transcriptional corepressor like 2; Rb-like 2; RB2; RBL2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols: RBL2
Molecular weight: 128,367 Da
Basal Isoelectric point: 7.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Rb-like 2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene