snRNP B1 Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. Belongs to the snRNP SmB/SmN family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2 F1|2 63.19 cM
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; cytosol; histone pre-mRNA 3'end processing complex; methylosome; nucleoplasm; nucleus; SMN-Sm protein complex; spliceosomal complex; telomerase holoenzyme complex; U1 snRNP; U12-type spliceosomal complex; U2 snRNP; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U2-type prespliceosome; U4 snRNP; U4/U6 x U5 tri-snRNP complex; U5 snRNP; U7 snRNP
Molecular Function:  histone pre-mRNA DCP binding; protein binding; RNA binding; telomerase RNA binding; U1 snRNP binding; U2 snRNP binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; protein methylation; RNA splicing; spliceosomal snRNP assembly
Reference #:  P27048 (UniProtKB)
Alt. Names/Synonyms: AL024368; AU018828; D10Mgi2; OTTMUSP00000016510; RSMB; Sm protein B; SM-; Sm-B; SM1; SM11; small nuclear ribonucleoprotein B; Small nuclear ribonucleoprotein-associated protein B; SmB; snRNP B1; snRNP-B; Snrpb
Gene Symbols: Snrpb
Molecular weight: 23,656 Da
Basal Isoelectric point: 10.91  Predict pI for various phosphorylation states
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snRNP B1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene