MCT1 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component:  cell junction; centrosome; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; plasma membrane; synapse
Molecular Function:  lactate transmembrane transporter activity; mevalonate transmembrane transporter activity; organic cyclic compound binding; protein homodimerization activity; symporter activity
Biological Process:  behavioral response to nutrient; cellular response to organic cyclic compound; centrosome cycle; glucose homeostasis; leukocyte migration; lipid metabolic process; mevalonate transport; plasma membrane lactate transport; pyruvate metabolic process; regulation of insulin secretion; response to food
Disease: Erythrocyte Lactate Transporter Defect; Hyperinsulinemic Hypoglycemia, Familial, 7; Monocarboxylate Transporter 1 Deficiency
Reference #:  P53985 (UniProtKB)
Alt. Names/Synonyms: FLJ36745; HHF7; MCT; MCT 1; MCT1; MGC44475; Monocarboxylate transporter 1; MOT1; SLC16A1; solute carrier family 16 (monocarboxylic acid transporters), member 1; Solute carrier family 16 member 1; solute carrier family 16, member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Gene Symbols: SLC16A1
Molecular weight: 53,944 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein