HSPG2 Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity. Found in the basement membranes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component:  basement membrane; extracellular region; Golgi lumen; lysosomal lumen; plasma membrane; plasma membrane protein complex
Molecular Function:  amyloid-beta binding; calcium ion binding; extracellular matrix structural constituent conferring compression resistance; low-density lipoprotein particle receptor binding; protein binding; protein C-terminus binding
Biological Process:  angiogenesis; brain development; cardiovascular system development; cell differentiation; cellular protein metabolic process; extracellular matrix organization; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; inflammatory response; lipid metabolic process; negative regulation of angiogenesis; receptor-mediated endocytosis; retinoid metabolic process
Disease: Dyssegmental Dysplasia, Silverman-handmaker Type; Schwartz-jampel Syndrome, Type 1
Reference #:  P98160 (UniProtKB)
Alt. Names/Synonyms: Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; HSPG2; LG3 peptide; Perlecan; perlecan proteoglycan; PGBM; PLC; PRCAN; SJA; SJS; SJS1
Gene Symbols: HSPG2
Molecular weight: 468,830 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene