ACR Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of mouse Ortholog: 15 E3|15 44.96 cM
Cellular Component:  acrosomal matrix; acrosomal vesicle; Golgi-associated vesicle; protein-containing complex
Molecular Function:  hydrolase activity; mannose binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  acrosome matrix dispersal; acrosome reaction; activation of adenylate cyclase activity; binding of sperm to zona pellucida; penetration of zona pellucida; protein catabolic process; response to steroid hormone; single fertilization
Reference #:  P23578 (UniProtKB)
Alt. Names/Synonyms: Acr; ACRO; Acrosin; Acrosin heavy chain; Acrosin light chain; acrosin prepropeptide; AI323726; MGC124043; preproacrosin
Gene Symbols: Acr
Molecular weight: 48,929 Da
Basal Isoelectric point: 9.48  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene