ACR Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of human Ortholog: 22q13.33
Cellular Component:  acrosomal matrix; extracellular region; Golgi-associated vesicle; protein-containing complex
Molecular Function:  amidase activity; copper ion binding; DNA binding; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity; zinc ion binding
Biological Process:  acrosome matrix dispersal; acrosome reaction; activation of adenylate cyclase activity; binding of sperm to zona pellucida; penetration of zona pellucida; response to steroid hormone; single fertilization
Reference #:  P10323 (UniProtKB)
Alt. Names/Synonyms: ACR; ACRO; Acrosin; Acrosin heavy chain; acrosin light and heavy chain prepropeptide; Acrosin light chain; ACRS; preproacrosin; proacrosin
Gene Symbols: ACR
Molecular weight: 45,847 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB