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ACR
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.21.10; Protease |
| Chromosomal Location of human Ortholog: 22q13.33 |
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Cellular Component:
acrosomal matrix; extracellular region; Golgi-associated vesicle; protein-containing complex
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Molecular Function:
amidase activity; copper ion binding; DNA binding; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity; zinc ion binding
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Biological Process:
acrosome matrix dispersal; acrosome reaction; activation of adenylate cyclase activity; binding of sperm to zona pellucida; penetration of zona pellucida; response to steroid hormone; single fertilization
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Reference #:
P10323
(UniProtKB)
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Alt. Names/Synonyms: ACR; ACRO; Acrosin; Acrosin heavy chain; acrosin light and heavy chain prepropeptide; Acrosin light chain; ACRS; preproacrosin; proacrosin
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Gene Symbols: ACR
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Molecular weight:
45,847 Da
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Basal Isoelectric point:
9.26
Predict pI for various phosphorylation states
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