nNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Belongs to the NOS family. Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase

Chromosomal Location of human Ortholog: 12q24.22

Cellular Component: cell periphery; cytoplasm; cytoskeleton; cytosol; dendritic spine; membrane raft; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; protein-containing complex; sarcolemma; sarcoplasmic reticulum; synapse

Molecular Function: arginine binding; cadmium ion binding; calcium-dependent protein binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; NADP binding; nitric-oxide synthase activity; protein binding; scaffold protein binding; sodium channel regulator activity; tetrahydrobiopterin binding; transmembrane transporter binding

Biological Process: arginine catabolic process; cell redox homeostasis; cellular response to growth factor stimulus; multicellular organismal response to stress; muscle contraction; myoblast fusion; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of calcium ion transport into cytosol; negative regulation of hydrolase activity; negative regulation of potassium ion transport; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of DNA-templated transcription; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of cardiac muscle contraction; regulation of ryanodine-sensitive calcium-release channel activity; regulation of sodium ion transport; response to heat; response to hormone; response to hypoxia; response to lipopolysaccharide; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; vasodilation; xenobiotic catabolic process

Disease: Pyloric Stenosis, Infantile Hypertrophic, 1

Reference #: P29475 (UniProtKB)

Alt. Names/Synonyms: bNOS; Constitutive NOS; IHPS1; N-NOS; NC-NOS; Neuronal NOS; Nitric oxide synthase 1; nitric oxide synthase 1 (neuronal); Nitric oxide synthase, brain; nNOS; NOS; NOS type I; NOS1; Peptidyl-cysteine S-nitrosylase NOS1

Gene Symbols: NOS1

Molecular weight: 160,970 Da

Basal Isoelectric point: 7.1 Predict pI for various phosphorylation states

CST Pathways: Angiogenesis | Growth And Differentiation Control by MAPKs

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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nNOS

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