nNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Belongs to the NOS family. Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q24.22
Cellular Component:  calyx of Held; caveola; cytoplasm; cytoskeleton; cytosol; dendritic spine; membrane raft; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; protein-containing complex; sarcolemma; sarcoplasmic reticulum; synapse; T-tubule; Z disc
Molecular Function:  arginine binding; cadmium ion binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; ion channel binding; NADP binding; nitric-oxide synthase activity; protein binding; scaffold protein binding; sodium channel regulator activity; tetrahydrobiopterin binding
Biological Process:  arginine catabolic process; cell redox homeostasis; cellular response to growth factor stimulus; exogenous drug catabolic process; multicellular organismal response to stress; myoblast fusion; negative regulation of calcium ion transport; negative regulation of calcium ion transport into cytosol; negative regulation of hydrolase activity; negative regulation of potassium ion transport; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; oxidation-reduction process; peptidyl-cysteine S-nitrosylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; positive regulation of histone acetylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of neurogenesis; regulation of ryanodine-sensitive calcium-release channel activity; regulation of sodium ion transport; response to heat; response to hypoxia; striated muscle contraction; vasodilation
Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
Reference #:  P29475 (UniProtKB)
Alt. Names/Synonyms: bNOS; Constitutive NOS; IHPS1; N-NOS; NC-NOS; Neuronal NOS; nitric oxide synthase 1; nitric oxide synthase 1 (neuronal); Nitric oxide synthase, brain; nNOS; NOS; NOS type I; NOS1; Peptidyl-cysteine S-nitrosylase NOS1
Gene Symbols: NOS1
Molecular weight: 160,970 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB