PLSCR3 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. Belongs to the phospholipid scramblase family. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of mouse Ortholog: 11 B3|11 42.9 cM
Cellular Component:  cytosol; membrane; mitochondrial inner membrane; mitochondrion; nucleus; plasma membrane
Molecular Function:  calcium ion binding; calcium-dependent protein binding; lead ion binding; magnesium ion binding; mercury ion binding; phospholipid scramblase activity; protein self-association; SH3 domain binding
Biological Process:  apoptotic process; cardiolipin biosynthetic process; cellular response to lipopolysaccharide; cholesterol homeostasis; glucose homeostasis; lipid transport; plasma membrane phospholipid scrambling; regulation of apoptotic process; regulation of release of cytochrome c from mitochondria
Reference #:  Q9JIZ9 (UniProtKB)
Alt. Names/Synonyms: 2210403O21Rik; 2610037N06Rik; Ca 2+ dependent phospholipid scramblase 3; Ca(2+)-dependent phospholipid scramblase 3; ESTM3; OTTMUSP00000006232; OTTMUSP00000006233; Phospholipid scramblase 3; PL scramblase 3; PLS3; Plscr3; X83310
Gene Symbols: Plscr3
Molecular weight: 31,803 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene