MIA3 Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. Belongs to the MIA/OTOR family. Tango1 subfamily. Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  endoplasmic reticulum exit site; endoplasmic reticulum lumen; endoplasmic reticulum membrane; Golgi membrane; integral component of membrane; intracellular membrane-bounded organelle
Molecular Function:  cargo receptor activity; protein binding
Biological Process:  cargo loading into COPII-coated vesicle; cell migration involved in sprouting angiogenesis; cellular protein metabolic process; cellular response to oxidised low-density lipoprotein particle stimulus; endoplasmic reticulum organization; ER to Golgi vesicle-mediated transport; exocytosis; lipoprotein transport; negative regulation of cell adhesion; negative regulation of cell migration; negative regulation of leukocyte cell-cell adhesion; negative regulation of lymphocyte migration; positive regulation of leukocyte migration; post-translational protein modification; protein localization to endoplasmic reticulum exit site; protein transport; wound healing
Reference #:  Q5JRA6 (UniProtKB)
Alt. Names/Synonyms: ARNT; C219 reactive peptide; C219-reactive peptide; D320; FLJ21469; FLJ39207; KIAA0268; melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; MIA family member 3, ER export factor; MIA SH3 domain ER export factor 3; MIA3; TANGO; TANGO1; TGO1; Transport and Golgi organization protein 1; Transport and Golgi organization protein 1 homolog; UNQ6077
Gene Symbols: MIA3
Molecular weight: 213,702 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein