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MAGE-A8
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA) |
| Chromosomal Location of human Ortholog: Xq28 |
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Cellular Component:
nucleus
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Molecular Function:
histone deacetylase binding; protein binding
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Biological Process:
negative regulation of transcription by RNA polymerase II
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Reference #:
P43361
(UniProtKB)
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Alt. Names/Synonyms: Cancer/testis antigen 1.8; cancer/testis antigen family 1, member 8; CT1.8; MAGA8; MAGE family member A8; MAGE-8 antigen; MAGE-A8; MAGE8; MAGEA8; melanoma antigen family A, 8; melanoma antigen family A8; Melanoma-associated antigen 8; MGC2182
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Gene Symbols: MAGEA8
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Molecular weight:
35,215 Da
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Basal Isoelectric point:
4.71
Predict pI for various phosphorylation states
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