N-Myc
Positively regulates the transcription of MYCNOS in neuroblastoma cells. Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Oncoprotein; Transcription factor |
Chromosomal Location of human Ortholog: 2p24.3 |
Cellular Component:
chromatin; nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; kinase binding; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
negative regulation of gene expression; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Disease: Feingold Syndrome 1; Megalencephaly-polydactyly Syndrome
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Reference #:
P04198
(UniProtKB)
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Alt. Names/Synonyms: BHLHE37; Class E basic helix-loop-helix protein 37; MODED; MYCN; MYCN proto-oncogene, bHLH transcription factor; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
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Gene Symbols: MYCN
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Molecular weight:
49,561 Da
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Basal Isoelectric point:
5.45
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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