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CHRD
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Belongs to the chordin family. Expressed at the highest level in liver. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 3q27.1 |
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Cellular Component:
extracellular space
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Molecular Function:
BMP binding; cytokine binding; protein binding
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Biological Process:
BMP signaling pathway involved in spinal cord dorsal/ventral patterning; dorsal/ventral pattern formation; floor plate development; negative regulation of BMP signaling pathway; negative regulation of cell migration; negative regulation of osteoblast differentiation; positive regulation of cell adhesion; positive regulation of mesenchymal cell proliferation; skeletal system development
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Reference #:
Q9H2X0
(UniProtKB)
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Alt. Names/Synonyms: Chordin; CHRD; MGC133038
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Gene Symbols: CHRD
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Molecular weight:
102,032 Da
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Basal Isoelectric point:
8.07
Predict pI for various phosphorylation states
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