BOLA3 Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1. Belongs to the BolA/IbaG family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 2p13.1
Cellular Component:  cytosol; iron-sulfur cluster assembly complex; mitochondrial matrix; mitochondrion; nuclear body
Molecular Function:  protein binding
Biological Process:  cell redox homeostasis; iron-sulfur cluster assembly; protein maturation by [4Fe-4S] cluster transfer
Disease: Multiple Mitochondrial Dysfunctions Syndrome 2
Reference #:  Q53S33 (UniProtKB)
Alt. Names/Synonyms: bolA family member 3; bolA homolog 3; bolA homolog 3 (E. coli); bolA-like 3; BolA-like protein 3; BOLA3; MMDS2
Gene Symbols: BOLA3
Molecular weight: 12,114 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein