TAF7 Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Belongs to the TAF7 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 18|18 B3
Cellular Component:  cytoplasm; male germ cell nucleus; MLL1 complex; nucleus; transcription factor TFIID complex; transcription factor TFTC complex; transcription regulator complex
Molecular Function:  DNA-binding transcription factor binding; H3K27me3 modified histone binding; histone acetyltransferase binding; nuclear thyroid hormone receptor binding; nuclear vitamin D receptor binding; P-TEFb complex binding; protein binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; TFIIH-class transcription factor complex binding; transcription cis-regulatory region binding
Biological Process:  DNA-templated transcription initiation; histone H3 acetylation; intracellular estrogen receptor signaling pathway; monoubiquitinated histone deubiquitination; monoubiquitinated histone H2A deubiquitination; mRNA transcription by RNA polymerase II; negative regulation of DNA-templated transcription; negative regulation of MHC class I biosynthetic process; negative regulation of MHC class II biosynthetic process; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein phosphorylation; regulation of DNA repair; regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter
Reference #:  Q9R1C0 (UniProtKB)
Alt. Names/Synonyms: 55kD; 55kDa; AI607308; BB007175; RNA polymerase II TBP-associated factor subunit F; TAF(II)55; Taf2; Taf2f; Taf7; TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kDa; TAFI; TAFII-55; TAFII55; TATA box binding protein (TBP) associated factor, RNA polymerase II, F, 55 kDa; TATA-box binding protein associated factor 7; Transcription initiation factor TFIID 55 kDa subunit; Transcription initiation factor TFIID subunit 7
Gene Symbols: Taf7
Molecular weight: 39,126 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below

TAF7

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein