CLEC4E A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. Expressed in monocytes and macrophages. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  cell projection; external side of plasma membrane; membrane; phagocytic cup; phagocytic vesicle membrane; plasma membrane
Molecular Function:  calcium ion binding; carbohydrate binding; glycolipid binding; pattern recognition receptor activity; protein binding
Biological Process:  antifungal innate immune response; biological process involved in interspecies interaction between organisms; defense response to bacterium; Fc-gamma receptor signaling pathway; immune response; innate immune response; pattern recognition receptor signaling pathway; positive regulation of cytokine production; T cell differentiation involved in immune response
Reference #:  Q9ULY5 (UniProtKB)
Alt. Names/Synonyms: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; C-type lectin domain family 4 member E; C-type lectin domain family 4, member E; C-type lectin superfamily member 9; CLC4E; CLEC4E; CLECSF9; Macrophage-inducible C-type lectin; MINCLE
Gene Symbols: CLEC4E
Molecular weight: 25,073 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB