| NMDAR1 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 9q34.3 |
| Cellular Component: cell surface; cytoplasm; dendrite; dendritic spine; endoplasmic reticulum membrane; excitatory synapse; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic cleft; synaptic membrane; synaptic vesicle; terminal bouton |
| Molecular Function: amyloid-beta binding; calcium channel activity; calcium ion binding; calmodulin binding; glutamate binding; glutamate-gated calcium ion channel activity; glycine binding; ligand-gated monoatomic ion channel activity; neurotransmitter binding; NMDA glutamate receptor activity; protein binding; protein-containing complex binding; signaling receptor activity |
| Biological Process: brain development; calcium ion homeostasis; calcium ion transmembrane import into cytosol; calcium-mediated signaling; cellular response to amyloid-beta; chemical synaptic transmission; excitatory chemical synaptic transmission; excitatory postsynaptic potential; ionotropic glutamate receptor signaling pathway; monoatomic cation transmembrane transport; monoatomic cation transport; positive regulation of calcium ion transport into cytosol; positive regulation of cysteine-type endopeptidase activity; positive regulation of excitatory postsynaptic potential; positive regulation of reactive oxygen species biosynthetic process; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription by RNA polymerase II; propylene metabolic process; protein heterotetramerization; regulation of membrane potential; regulation of monoatomic cation transmembrane transport; regulation of neuronal synaptic plasticity; regulation of synaptic plasticity; response to ethanol; response to glycine; visual learning |
| Disease: Developmental And Epileptic Encephalopathy 101; Mental Retardation, Autosomal Dominant 8; Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive |
| Reference #: Q05586 (UniProtKB) |
| Alt. Names/Synonyms: GluN1; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate ionotropic receptor NMDA type subunit 1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; MRD8; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NDHMSD; NDHMSR; NMD-R1; NMDA1; NMDAR1; NMDZ1; NR1 |
| Gene Symbols: GRIN1 |
| Molecular weight: 105,373 Da |
| Basal Isoelectric point: 9.03 Predict pI for various phosphorylation states |
| CST Pathways: Alzheimer's Disease | Parkinson's Disease |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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NMDAR1 |
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