LACTB Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism. Belongs to the peptidase S12 family. Expressed predominantly in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.-.-; Mitochondrial; Protease
Chromosomal Location of mouse Ortholog: 9|9 C
Cellular Component:  cytosol; mitochondrion
Molecular Function:  hydrolase activity; identical protein binding; peptidase activity
Biological Process:  lipid metabolic process; proteolysis; regulation of lipid metabolic process
Reference #:  Q9EP89 (UniProtKB)
Alt. Names/Synonyms: LACT-1; Lact1; lactamase, beta; Lactb; mitochondrial ribosomal protein L56; Mrp; Mrpl56; serine beta lactamase-like protein; Serine beta-lactamase-like protein LACTB, mitochondrial
Gene Symbols: Lactb
Molecular weight: 60,705 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene