DNAH8 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of mouse Ortholog: 17|17 A3.3
Cellular Component:  axoneme; cell projection; cilium; cytoplasm; cytoskeleton; dynein complex; microtubule; motile cilium; outer dynein arm; sperm flagellum
Molecular Function:  ATP binding; dynein intermediate chain binding; dynein light intermediate chain binding; microtubule motor activity; minus-end-directed microtubule motor activity; nucleotide binding
Biological Process:  microtubule-based movement; outer dynein arm assembly
Reference #:  Q91XQ0 (UniProtKB)
Alt. Names/Synonyms: ATPase; Axonemal beta dynein heavy chain 8; axonemal dynein heavy chain 8 Dnahc8; Ciliary dynein heavy chain 8; Dnah; DNAH8; Dnahc8; DYH8; Dynein heavy chain 8, axonemal; dynein, axon, heavy chain 8; dynein, axonemal, heavy chain 8; Hst6.7; Hst6.7b; P1-Loop
Gene Symbols: Dnahc8
Molecular weight: 541,238 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene