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DNAH8
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of human Ortholog: 6p21.2 |
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Cellular Component:
axonemal dynein complex; axoneme; microtubule; outer dynein arm; sperm flagellum
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Molecular Function:
ATP binding; dynein intermediate chain binding; dynein light intermediate chain binding; microtubule motor activity; minus-end-directed microtubule motor activity
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Biological Process:
cilium movement involved in cell motility; cilium-dependent cell motility; microtubule-based movement; outer dynein arm assembly
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Disease: Spermatogenic Failure 46
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Reference #:
Q96JB1
(UniProtKB)
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Alt. Names/Synonyms: ATPase; Axonemal beta dynein heavy chain 8; Ciliary dynein heavy chain 8; DNAH8; DYH8; Dynein axonemal heavy chain 8; Dynein heavy chain 8, axonemal; dynein, axonemal, heavy chain 8; dynein, axonemal, heavy polypeptide 8; FLJ25850; FLJ36115; FLJ36334; hdhc9
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Gene Symbols: DNAH8
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Molecular weight:
514,664 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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