DNAH8 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component:  axonemal dynein complex; dynein complex; microtubule
Molecular Function:  ATP binding; microtubule motor activity
Biological Process:  cilium-dependent cell motility
Reference #:  Q96JB1 (UniProtKB)
Alt. Names/Synonyms: ATPase; Axonemal beta dynein heavy chain 8; Ciliary dynein heavy chain 8; DNAH8; DYH8; Dynein heavy chain 8, axonemal; dynein, axonemal, heavy chain 8; dynein, axonemal, heavy polypeptide 8; FLJ25850; FLJ36115; FLJ36334; hdhc9
Gene Symbols: DNAH8
Molecular weight: 514,664 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene