SIRT5 NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. Belongs to the sirtuin family. Class III subfamily. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial
Chromosomal Location of mouse Ortholog: 13|13 A4
Cellular Component:  cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; nucleus
Molecular Function:  metal ion binding; NAD+ binding; protein binding; protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; transferase activity; zinc ion binding
Biological Process:  negative regulation of cardiac muscle cell apoptotic process; negative regulation of reactive oxygen species metabolic process; peptidyl-lysine demalonylation; peptidyl-lysine desuccinylation; protein deglutarylation; protein demalonylation; protein desuccinylation; regulation of ketone biosynthetic process; regulation of succinate dehydrogenase activity; response to ischemia
Reference #:  Q8K2C6 (UniProtKB)
Alt. Names/Synonyms: 0610012J09Rik; 1500032M05Rik; AV001953; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; Regulatory protein SIR2 homolog 5; SIR2-like protein 5; Sir2l5; SIR5; Sirt5; sirtuin 5; sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
Gene Symbols: Sirt5
Molecular weight: 34,134 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein