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KREMEN2
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 17|17 A3.3 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
limb development; multicellular organism development; negative regulation of ossification; Wnt signaling pathway
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Reference #:
Q8K1S7
(UniProtKB)
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Alt. Names/Synonyms: 2900054E04Rik; Dickkopf receptor 2; KREM2; Kremen protein 2; Kremen2; kringle containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; Krm; Krm2
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Gene Symbols: Kremen2
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Molecular weight:
49,170 Da
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Basal Isoelectric point:
7.47
Predict pI for various phosphorylation states
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