KREMEN2 Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  early endosome membrane; integral component of membrane; plasma membrane
Biological Process:  limb development; negative regulation of canonical Wnt signaling pathway; negative regulation of ossification; Wnt signaling pathway
Reference #:  Q8NCW0 (UniProtKB)
Alt. Names/Synonyms: Dickkopf receptor 2; KREM2; Kremen protein 2; KREMEN2; kringle containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; KRM2; MGC10791; MGC16709
Gene Symbols: KREMEN2
Molecular weight: 48,849 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein