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KREMEN2
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 16p13.3 |
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Cellular Component:
early endosome membrane; integral component of membrane; plasma membrane
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Biological Process:
limb development; negative regulation of canonical Wnt signaling pathway; negative regulation of ossification; Wnt signaling pathway
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Reference #:
Q8NCW0
(UniProtKB)
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Alt. Names/Synonyms: Dickkopf receptor 2; KREM2; Kremen protein 2; KREMEN2; kringle containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; KRM2; MGC10791; MGC16709
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Gene Symbols: KREMEN2
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Molecular weight:
48,849 Da
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Basal Isoelectric point:
7.44
Predict pI for various phosphorylation states
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