RAB11FIP4 Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Present at high level in testis (at protein level). Weakly expressed in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  cleavage furrow; endocytic vesicle; endosome; midbody; perinuclear region of cytoplasm; recycling endosome membrane; spindle
Molecular Function:  ADP-ribosylation factor binding; calcium ion binding; protein binding; protein homodimerization activity; Rab GTPase binding
Biological Process:  neural retina development; positive regulation of G1 to G0 transition; regulation of cytokinesis; viral process
Reference #:  Q86YS3 (UniProtKB)
Alt. Names/Synonyms: ARFO2; Arfophilin-2; FIP4-Rab11; FLJ00131; KIAA1821; MGC11316; MGC126566; RAB11 family interacting protein 4; RAB11 family interacting protein 4 (class II); Rab11 family-interacting protein 4; Rab11-FIP4; RAB11FIP4; RFIP4
Gene Symbols: RAB11FIP4
Molecular weight: 71,928 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene