DSG4 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 18 A2|18 11.35 cM
Cellular Component:  cell junction; cell-cell junction; desmosome; membrane; plasma membrane
Molecular Function:  calcium ion binding; metal ion binding
Biological Process:  anagen; BMP signaling pathway; cell adhesion; cell-cell adhesion; hair follicle development; homophilic cell adhesion via plasma membrane adhesion molecules; keratinocyte differentiation
Reference #:  Q7TMD7 (UniProtKB)
Alt. Names/Synonyms: CDHF13; desmoglein 4; Desmoglein-4; Dsg4; lah; lanceolate hair; MGC124398
Gene Symbols: Dsg4
Molecular weight: 114,449 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene