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DSG4
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 18 A2|18 11.35 cM |
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Cellular Component:
cell junction; cell-cell junction; desmosome; membrane; plasma membrane
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Molecular Function:
calcium ion binding; metal ion binding
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Biological Process:
anagen; BMP signaling pathway; cell adhesion; cell-cell adhesion; hair follicle development; homophilic cell adhesion via plasma membrane adhesion molecules; keratinocyte differentiation
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Reference #:
Q7TMD7
(UniProtKB)
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Alt. Names/Synonyms: CDHF13; desmoglein 4; Desmoglein-4; Dsg4; lah; lanceolate hair; MGC124398
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Gene Symbols: Dsg4
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Molecular weight:
114,449 Da
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Basal Isoelectric point:
4.58
Predict pI for various phosphorylation states
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