DSG4 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component:  cornified envelope; desmosome; integral component of membrane; plasma membrane
Molecular Function:  calcium ion binding
Biological Process:  BMP signaling pathway; cornification; hair follicle development; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization
Disease: Hypotrichosis 6
Reference #:  Q86SJ6 (UniProtKB)
Alt. Names/Synonyms: Cadherin family member 13; CDGF13; CDH family member 13; CDHF13; desmoglein 4; Desmoglein-4; DSG4; LAH
Gene Symbols: DSG4
Molecular weight: 113,824 Da
Basal Isoelectric point: 4.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein