NHE1 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Kidney and intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 1p36.11
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cation-transporting ATPase complex; cell surface; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; integral component of plasma membrane; intercalated disc; lamellipodium; membrane raft; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; T-tubule
Molecular Function:  calcium-dependent protein binding; calmodulin binding; molecular adaptor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein binding, bridging; protein phosphatase 2B binding; sodium:proton antiporter activity; sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential; solute:proton antiporter activity
Biological Process:  cardiac muscle cell contraction; cardiac muscle cell differentiation; cell migration; cellular response to acidic pH; cellular response to antibiotic; cellular response to cold; cellular response to electrical stimulus; cellular response to epinephrine stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to mechanical stimulus; cellular sodium ion homeostasis; hyaluronan catabolic process; ion transport; maintenance of cell polarity; negative regulation of apoptotic process; neuron death; positive regulation of action potential; positive regulation of apoptotic process; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium:sodium antiporter activity; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth; positive regulation of mitochondrial membrane permeability; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; protein complex oligomerization; proton transmembrane transport; regulation of cardiac muscle cell membrane potential; regulation of cardiac muscle contraction by calcium ion signaling; regulation of focal adhesion assembly; regulation of intracellular pH; regulation of pH; regulation of sensory perception of pain; regulation of stress fiber assembly; regulation of the force of heart contraction by cardiac conduction; response to acidic pH; response to muscle stretch; sodium ion export across plasma membrane; sodium ion import across plasma membrane
Disease: Lichtenstein-knorr Syndrome
Reference #:  P19634 (UniProtKB)
Alt. Names/Synonyms: APNH; APNH1; FLJ42224; LIKNS; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter, amiloride-sensitive; Na-Li countertransporter; Na/H+ exchanger; NHE-1; NHE1; PPP1R143; protein phosphatase 1, regulatory subunit 143; SL9A1; SLC9A1; Sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); Solute carrier family 9 member 1; solute carrier family 9 member A1; solute carrier family 9, isoform A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Gene Symbols: SLC9A1
Molecular weight: 90,763 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene