UBE2H Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. Belongs to the ubiquitin-conjugating enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q32.2
Cellular Component:  cytosol
Molecular Function:  ATP binding; protein binding; ubiquitin-protein transferase activity
Biological Process:  proteasome-mediated ubiquitin-dependent protein catabolic process; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein ubiquitination
Reference #:  P62256 (UniProtKB)
Alt. Names/Synonyms: (E3-independent) E2 ubiquitin-conjugating enzyme H; E2 ubiquitin-conjugating enzyme H; E2-20K; GID complex subunit 3, UBC8 homolog; GID3; UBC8; UBCH; UbcH2; UBE2H; Ubiquitin carrier protein H; ubiquitin conjugating enzyme E2 H; ubiquitin conjugating enzyme E2H; Ubiquitin-conjugating enzyme E2 H; Ubiquitin-conjugating enzyme E2-20K; ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8); ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); Ubiquitin-protein ligase H
Gene Symbols: UBE2H
Molecular weight: 20,655 Da
Basal Isoelectric point: 4.55  Predict pI for various phosphorylation states
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UBE2H

Protein Structure Not Found.


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