WFS1 Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5|5 B3
Cellular Component:  endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; integral component of synaptic vesicle membrane; membrane
Molecular Function:  activating transcription factor binding; ATPase binding; calcium-dependent protein binding; calmodulin binding; ubiquitin protein ligase binding
Biological Process:  calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; glucose homeostasis; kidney development; negative regulation of ATF6-mediated unfolded protein response; negative regulation of DNA-binding transcription factor activity; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of programmed cell death; negative regulation of transcription by RNA polymerase II; negative regulation of type B pancreatic cell apoptotic process; nervous system process; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein stabilization; regulation of cell cycle; renal water homeostasis; response to endoplasmic reticulum stress; sensory perception of sound; ubiquitin-dependent ERAD pathway; visual perception
Reference #:  P56695 (UniProtKB)
Alt. Names/Synonyms: AI481085; Wfs1; Wolfram syndrome 1 homolog (human); Wolfram syndrome 1 protein homolog; Wolframin
Gene Symbols: Wfs1
Molecular weight: 100,579 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene