CNTFR Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily. Nervous system and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of mouse Ortholog: 4 A5|4 21.81 cM
Cellular Component:  anchored component of membrane; apical plasma membrane; ciliary neurotrophic factor receptor complex; CNTFR-CLCF1 complex; external side of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  ciliary neurotrophic factor receptor activity; cytokine binding; cytokine receptor activity; interleukin-27 receptor binding; protein binding; signaling receptor binding
Biological Process:  brainstem development; ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; positive regulation of cell proliferation; sex differentiation; skeletal muscle organ development; suckling behavior
Reference #:  O88507 (UniProtKB)
Alt. Names/Synonyms: ciliary neurotrophic factor receptor; Ciliary neurotrophic factor receptor subunit alpha; Cntf; CNTF receptor subunit alpha; Cntfr; CNTFR-alpha; Cntfralpha; OTTMUSP00000007063; OTTMUSP00000007064
Gene Symbols: Cntfr
Molecular weight: 40,801 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene