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PSMB10
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.25.1; Protease; Proteasome complex |
| Chromosomal Location of Human Ortholog: 16q22.1 |
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Cellular Component:
cytosol; nucleoplasm; proteasome complex; proteasome core complex; proteasome core complex, beta-subunit complex; spermatoproteasome complex
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Molecular Function:
protein binding; threonine-type endopeptidase activity
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Biological Process:
anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell morphogenesis; Fc-epsilon receptor signaling pathway; humoral immune response; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell proliferation; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway
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Disease: Proteasome-associated Autoinflammatory Syndrome 5
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Reference #:
P40306
(UniProtKB)
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Alt. Names/Synonyms: beta2i; LMP10; Low molecular mass protein 10; Macropain subunit MECl-1; MECL1; MGC1665; Multicatalytic endopeptidase complex subunit MECl-1; proteasome (prosome, macropain) subunit, beta type, 10; proteasome 20S subunit beta 10; proteasome catalytic subunit 2i; Proteasome MECl-1; proteasome subunit beta 10; proteasome subunit beta 7i; Proteasome subunit beta type-10; Proteasome subunit beta-2i; proteasome subunit beta2i; proteasome subunit MECL1; PSB10; PSMB10
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Gene Symbols: PSMB10
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Molecular weight:
28,936 Da
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Basal Isoelectric point:
7.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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