PSMB10 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of human Ortholog: 16q22.1
Cellular Component:  cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, beta-subunit complex; spermatoproteasome complex
Molecular Function:  endopeptidase activity; protein binding; threonine-type endopeptidase activity
Biological Process:  cell morphogenesis; humoral immune response; proteasomal protein catabolic process; T cell proliferation
Disease: Proteasome-associated Autoinflammatory Syndrome 5
Reference #:  P40306 (UniProtKB)
Alt. Names/Synonyms: beta2i; LMP10; Low molecular mass protein 10; Macropain subunit MECl-1; MECL1; MGC1665; Multicatalytic endopeptidase complex subunit MECl-1; proteasome (prosome, macropain) subunit, beta type, 10; proteasome 20S subunit beta 10; proteasome catalytic subunit 2i; Proteasome MECl-1; proteasome subunit beta 10; proteasome subunit beta 7i; Proteasome subunit beta type-10; Proteasome subunit beta-2i; proteasome subunit beta2i; proteasome subunit MECL1; PSB10; PSMB10
Gene Symbols: PSMB10
Molecular weight: 28,936 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene