MGC4172 Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  extracellular region
Molecular Function:  17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; 3-keto sterol reductase activity; cycloeucalenone reductase activity; estradiol 17-beta-dehydrogenase activity; nucleotide binding
Biological Process:  estrogen biosynthetic process; steroid biosynthetic process
Reference #:  Q6UWP2 (UniProtKB)
Alt. Names/Synonyms: 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; ARPG836; dehydrogenase/reductase (SDR family) member 11; dehydrogenase/reductase 11; Dehydrogenase/reductase SDR family member 11; DHR11; DHRS11; Estradiol 17-beta-dehydrogenase; FLJ39232; MGC4172; SDR24C1; short chain dehydrogenase/reductase family 24C, member 1; short-chain dehydrogenase/reductase; Short-chain dehydrogenase/reductase family 24C member 1; spDHRS11
Gene Symbols: DHRS11
Molecular weight: 28,308 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene