|
MGC4172
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.-.-.-; Oxidoreductase; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 17q12 |
|
Cellular Component:
extracellular region
|
|
Molecular Function:
17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; 3-keto sterol reductase activity; cycloeucalenone reductase activity; estradiol 17-beta-dehydrogenase activity; nucleotide binding
|
|
Biological Process:
estrogen biosynthetic process; steroid biosynthetic process
|
|
Reference #:
Q6UWP2
(UniProtKB)
|
|
Alt. Names/Synonyms: 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; ARPG836; dehydrogenase/reductase (SDR family) member 11; dehydrogenase/reductase 11; Dehydrogenase/reductase SDR family member 11; DHR11; DHRS11; Estradiol 17-beta-dehydrogenase; FLJ39232; MGC4172; SDR24C1; short chain dehydrogenase/reductase family 24C, member 1; short-chain dehydrogenase/reductase; Short-chain dehydrogenase/reductase family 24C member 1; spDHRS11
|
|
Gene Symbols: DHRS11
|
|
Molecular weight:
28,308 Da
|
|
Basal Isoelectric point:
6.17
Predict pI for various phosphorylation states
|
