GUF1 Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.-; Mitochondrial
Chromosomal Location of Human Ortholog: 4p12
Cellular Component:  mitochondrial inner membrane; mitochondrial matrix
Molecular Function:  GTP binding; GTPase activity; ribosome binding
Biological Process:  positive regulation of translation; translation
Disease: Epileptic Encephalopathy, Early Infantile, 40
Reference #:  Q8N442 (UniProtKB)
Alt. Names/Synonyms: EF-4; EF4; EIEE40; Elongation factor 4 homolog; FLJ13220; GTP-binding protein GUF1 homolog; GTPase GUF1; GTPase of unknown function 1; GUF1; GUF1 GTPase homolog (S. cerevisiae); GUF1 homolog, GTPase; Ribosomal back-translocase; Translation factor GUF1, mitochondrial
Gene Symbols: GUF1
Molecular weight: 74,328 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB