HECTD4 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral
Chromosomal Location of human Ortholog: 12q24.13
Cellular Component:  integral component of membrane
Molecular Function:  ubiquitin-protein transferase activity
Biological Process:  glucose homeostasis; glucose metabolic process; protein ubiquitination
Reference #:  Q9Y4D8 (UniProtKB)
Alt. Names/Synonyms: AF-1 specific protein phosphatase; C12ord51; C12orf51; chromosome 12 open reading frame 51; DKFZp586O1022; FLJ10510; FLJ30092; FLJ30208; FLJ34154; HECD4; HECT domain containing E3 ubiquitin protein ligase 4; HECT domain E3 ubiquitin protein ligase 4; HECT domain-containing protein 4; HECT-type E3 ubiquitin transferase HECTD4; HECTD4; HEEL; K0614; KIAA0614; MGC126531; POTAGE; probable E3 ubiquitin-protein ligase C12orf51; Probable E3 ubiquitin-protein ligase HECTD4; Probable E3 ubiquitin-protein ligase KIAA0614; transmembrane protein C12orf51
Gene Symbols: HECTD4
Molecular weight: 439,344 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein