UBC9 Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Belongs to the ubiquitin-conjugating enzyme family. Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. Note: This description may include information from UniProtKB.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO conjugating system; SUMO ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; nuclear envelope; nuclear pore; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; SUMO ligase complex; synaptonemal complex; transferase complex

Molecular Function: ATP binding; enzyme binding; HLH domain binding; protein binding; RING-like zinc finger domain binding; small protein activating enzyme binding; SUMO conjugating enzyme activity; SUMO transferase activity; transcription coregulator binding; transcription factor binding

Biological Process: cell division; chromosome segregation; mitotic nuclear membrane reassembly; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; nuclear export; positive regulation of cell migration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of SUMO transferase activity; protein modification process; protein sumoylation; ubiquitin-dependent protein catabolic process

Reference #: P63279 (UniProtKB)

Alt. Names/Synonyms: C358B7.1; p18; RING-type E3 SUMO transferase UBC9; SUMO-1-protein ligase; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; UBC9; UBCE9; UBE2I; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; ubiquitin conjugating enzyme 9; ubiquitin conjugating enzyme E2 I; ubiquitin conjugating enzyme E2I; Ubiquitin-conjugating enzyme E2 I; ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-protein ligase E2I; Ubiquitin-protein ligase I

Gene Symbols: UBE2I

Molecular weight: 18,007 Da

Basal Isoelectric point: 8.87 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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UBC9

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