|
HSD3B2 iso2
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Belongs to the 3-beta-HSD family. Expressed in adrenal gland, testis and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.1.1.145; EC 5.3.3.1; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 1p12 |
|
Cellular Component:
cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intercellular bridge; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial membrane; nucleolus; smooth endoplasmic reticulum membrane
|
|
Molecular Function:
3-beta-hydroxy-delta5-steroid dehydrogenase activity; cholesterol dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; steroid delta-isomerase activity
|
|
Biological Process:
androgen biosynthetic process; C21-steroid hormone metabolic process; hippocampus development; response to corticosterone; steroid biosynthetic process
|
|
Reference #:
P26439-2
(UniProtKB)
|
|
Alt. Names/Synonyms: 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD adrenal and gonadal type; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BHS2; delta 5-delta 4-isomerase type II; Delta-5-3-ketosteroid isomerase; HSD3B; HSD3B2; HSD3B2 iso2; HSDB; HSDB3B; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Progesterone reductase; SDR11E2; short chain dehydrogenase/reductase family 11E, member 2; Steroid Delta-isomerase
|
|
Gene Symbols: HSD3B2
|
|
Molecular weight:
24,987 Da
|
|
Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
|
