TNRC6C Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  cytosol
Molecular Function:  protein binding; RNA binding
Biological Process:  gene silencing by miRNA; miRNA mediated inhibition of translation; negative regulation of gene expression; positive regulation of gene expression; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; posttranscriptional gene silencing by RNA; regulation of megakaryocyte differentiation; Wnt signaling pathway, calcium modulating pathway
Reference #:  Q9HCJ0 (UniProtKB)
Alt. Names/Synonyms: AC021593.2; FLJ20015; KIAA1582; TNR6C; TNRC6C; trinucleotide repeat containing 6C; trinucleotide repeat containing adaptor 6C; Trinucleotide repeat-containing gene 6C protein
Gene Symbols: TNRC6C
Molecular weight: 175,964 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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