JHDM1D Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  histone demethylase activity (H3-K27 specific); histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); histone demethylase activity (H4-K20 specific); iron ion binding; methylated histone binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; zinc ion binding
Biological Process:  histone H3-K27 demethylation; histone H3-K36 demethylation; histone H3-K9 demethylation; histone H4-K20 demethylation; midbrain development; oxidation-reduction process; positive regulation of transcription, DNA-templated
Reference #:  Q6ZMT4 (UniProtKB)
Alt. Names/Synonyms: Histone lysine demethylase JHDM1D; JHDM1D; JmjC domain-containing histone demethylation protein 1D; jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); jumonji C domain-containing histone demethylase 1 homolog D; KDM7; KDM7A; KIAA1718; Lysine-specific demethylase 7A
Gene Symbols: KDM7A
Molecular weight: 106,557 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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