RMI1 Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Belongs to the RMI1 family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q21.32
Cellular Component:  nuclear body; nucleoplasm
Molecular Function:  nucleotide binding; protein binding
Biological Process:  DNA replication; glucose homeostasis; multicellular organism growth; reduction of food intake in response to dietary excess; regulation of signal transduction by p53 class mediator; response to glucose
Reference #:  Q9H9A7 (UniProtKB)
Alt. Names/Synonyms: BLAP75; BLM-Associated Polypeptide, 75 kDa; BLM-associated protein 75 kDa; BLM-associated protein of 75 kDa; C9orf76; FAAP75; FLJ12888; homolog of yeast RecQ-mediated genome instability 1 (RMI1); RecQ mediated genome instability 1; RecQ-mediated genome instability protein 1; RMI1; RMI1, RecQ mediated genome instability 1, homolog; RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae); RP11-346I8.1
Gene Symbols: RMI1
Molecular weight: 70,144 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
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RMI1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein