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NFkB-p105
a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. NFkB1-p105 is processed into the shorter form NFkB1-p50 either cotranslationally or posttranslationally. p50/RelA and p50/RelB heterodimers are transcriptional activators. p50 homodimers are transcriptional repressor, but can act as a transcriptional activators when associated with BCL3. p50 binds to the kappa-B consensus sequence in enhancer region of genes involved in immune response and acute phase reactions. NFKB1-p105 binds Cot, inhibiting Cot-induced MAPK signaling; active Cot is released by proteasome-dependent degradation of p105. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 4q24 |
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Cellular Component:
cytoplasm; cytosol; extracellular region; I-kappaB/NF-kappaB complex; mitochondrion; nucleoplasm; nucleus; secretory granule lumen; specific granule lumen
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Molecular Function:
actinin binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding
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Biological Process:
apoptotic process; cellular response to angiotensin; cellular response to dsRNA; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to nicotine; cellular response to tumor necrosis factor; Fc-epsilon receptor signaling pathway; inflammatory response; interleukin-1-mediated signaling pathway; membrane protein intracellular domain proteolysis; negative regulation of apoptotic process; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of cellular protein metabolic process; negative regulation of cholesterol transport; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription by RNA polymerase II; negative regulation of vitamin D biosynthetic process; neutrophil degranulation; positive regulation of canonical Wnt signaling pathway; positive regulation of hyaluronan biosynthetic process; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; positive regulation of miRNA metabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of type I interferon production; response to muscle stretch; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transcription by RNA polymerase II
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Disease: Immunodeficiency, Common Variable, 12
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Reference #:
P19838
(UniProtKB)
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Alt. Names/Synonyms: CVID12; DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappa-B1; NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; NFKB1/p105; NFKB1/p50; nuclear factor kappa B subunit 1; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
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Gene Symbols: NFKB1
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Molecular weight:
105,356 Da
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Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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