AARSL Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of human Ortholog: 6p21.1
Cellular Component:  mitochondrion
Molecular Function:  alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; protein binding; zinc ion binding
Biological Process:  alanyl-tRNA aminoacylation; aminoacyl-tRNA metabolism involved in translational fidelity; mitochondrial alanyl-tRNA aminoacylation
Disease: Combined Oxidative Phosphorylation Deficiency 8; Leukoencephalopathy, Progressive, With Ovarian Failure
Reference #:  Q5JTZ9 (UniProtKB)
Alt. Names/Synonyms: AARS2; AARSL; alanine tRNA ligase 2, mitochondrial (putative); Alanine--tRNA ligase; Alanine--tRNA ligase, mitochondrial; Alanyl-tRNA synthetase; alanyl-tRNA synthetase 2, mitochondrial; alanyl-tRNA synthetase 2, mitochondrial (putative); alanyl-tRNA synthetase like; Alanyl-tRNA synthetase-like; AlaRS; bA444E17.1; COXPD8; KIAA1270; LKENP; MT-ALARS; MTALARS; Probable alanyl-tRNA synthetase, mitochondrial; SYAM
Gene Symbols: AARS2
Molecular weight: 107,340 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein